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  5. Studies on the Enantiomers of ZJM-289:Synthesis,Antiplatelet and Antithrombotic Activities,and Neuro

Studies on the Enantiomers of ZJM-289:Synthesis,Antiplatelet and Antithrombotic Activities,and Neuro

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：bimzhouhong
【摘 要】
：
ZJM-289 is a potent racemic agent which inhibits both platelet aggregation and thrombosis superior to a known anti-ischemic stroke drug 3-n-butylphthalide (NBP).1 Herein,synthesis and biological evalu
【作 者】
：
Xiaoli Wang Jingjing Ling Jinyi Xu Hui Ji Sixun Peng Yihua Zhang 
【机 构】
：
Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
【发表日期】
：
2012年8期
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　　ZJM-289 is a potent racemic agent which inhibits both platelet aggregation and thrombosis superior to a known anti-ischemic stroke drug 3-n-butylphthalide (NBP).1 Herein,synthesis and biological evaluation of the enantiomers of ZJM-289 are described.It was observed that the two enantiomers,(S)-ZJM-289 and(R)-ZJM-289,appeared to be almost as effective as ZJM-289 in inhibiting adenosine diphosphate (ADP),thrombin(TH) and arachidonic acid(AA) induced platelet aggregation in vitro and thrombus formation in rats,and in protecting against collagen and adrenaline-induced thrombosis in mice.
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