Scaffold Hopping:Discovery of Quinazoline Derivatives as Novel Anti-cancer Agents

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：rosy888888

【摘要】

：

【作者】

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張許永蕭暉議林文星徐祖安陳炯東趙宇生夏克山謝興邦

【出处】

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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

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2012年8期

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　　In our preliminary result,compound 1,which contained the urea side chain and diphenylfuranopyrimidine core structure,possessed Aurora A kinase inhibition with an IC50 of 43 nM and anti-proliferation against HCT-116 with an IC50 of 400 nM.In the present work,we applied the scaffold-hopping strategy to explore the structure-activity relationship of this series of kinase inhibitors.

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Scaffold Hopping:Discovery of Quinazoline Derivatives as Novel Anti-cancer Agents

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