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万古霉素属于糖肽类药物,主要用于治疗耐甲氧西林葡萄球菌(Methicillin resistant staphylococcus,MRSA)及敏感肠球菌所致各种严重感染,是儿科革兰阳性菌感染的常用抗生素,适用于MRSA、甲氧西林耐药凝固酶阴性葡萄球菌(MRCNS)、肠球菌属、耐青霉素肺炎链球菌和多重耐药肺炎链球菌(MDRSP)等所致感染。对于复杂性感染包括由MRSA引起的心内膜炎、骨髓炎、脑膜炎、医院获得性肺炎,万古霉素血药谷浓度应达到15~20 mg/L,以保证达到治疗目标和提高临床有效率[1]。万古霉素主要给药途径为注射给药,蛋白结合率
Vancomycin is a glycopeptide drug used mainly in the treatment of various serious infections caused by methicillin-resistant staphylococcus (MRSA) and susceptible enterococci. It is a common antibiotic used in pediatric gram-positive infections and is suitable for MRSA, methicillin-resistant coagulase-negative staphylococci (MRCNS), Enterococcus, penicillin-resistant Streptococcus pneumoniae and multi-resistant Streptococcus pneumoniae (MDRSP) and other infections. Endocarditis, osteomyelitis, meningitis, nosocomial pneumonia caused by MRSA, and vancomycin blood levels should reach 15-20 mg / L for complicated infections, including MRSA, in order to achieve therapeutic goals and improve clinical outcomes Efficiency [1]. The main route of administration of vancomycin for injection, protein binding rate