论文部分内容阅读
目的探讨乳腺浸润性导管癌MRI增强形态类型与年龄的相关性及其病理基础。方法收集经病理学证实的乳腺浸润性导管癌97例,均进行了MRI动态增强检查。2名放射科医生独立阅片确定肿瘤MRI增强后形态类型(肿块/非肿块样强化)及大小。2名病理科医生确定浸润性导管癌成分的组织学分级及肿瘤内是否含有导管内原位癌(ductal carcinoma in situ,DCIS)。分析MRI增强形态类型与年龄段的相关性,青年与中、老年MRI增强形态类型是否有显著差异,肿块与非肿块型乳腺癌病变大小、浸润性导管癌成份组织学分级及DCIS存在与否的差异性。结果 MRI增强形态类型与年龄显著相关(P=0.000);40岁(含)以下青年中的非肿块型乳腺癌比40岁以上中老年的明显增多(P=0.000)。非肿块型乳腺癌大小大于肿块型(P=0.022)。非肿块型乳腺癌中病理含DCIS者明显多于肿块型乳腺癌(P=0.000),且前者浸润性导管癌成分的组织学分级明显低于后者(P=0.006)。结论非肿块型乳腺癌更易发生于青年,肿块型乳腺癌更易发生于中老年。非肿块型乳腺癌与存在DCIS显著相关,但浸润性导管癌成分组织学分级相对较低,其恶性程度未必差于肿块型乳腺癌。
Objective To investigate the correlation between MRI enhanced morphology and age of breast invasive ductal carcinoma and its pathological basis. Methods Ninety-seven cases of invasive ductal carcinoma of the breast confirmed by pathology were collected and dynamically examined by MRI. Two radiologists performed an independent reading to determine the type of morphology (lump / non-lump-like enhancement) and size of the tumor after MRI enhancement. Two pathologists determined the histological grade of the invasive ductal carcinoma and the presence of ductal carcinoma in situ (DCIS) in the tumor. To analyze whether there is a significant difference in the morphological types of MRI enhancement between young and middle-aged and old patients, the size of lesion with or without breast cancer, the histological grade of invasive ductal carcinoma and the presence of DCIS difference. Results The type of MRI enhancement was significantly associated with age (P = 0.000). Non-tumor type breast cancer was significantly higher in patients younger than 40 years (P = 0.000) than in those over 40 years old. Non-bulky breast cancer was larger than the size of the tumor (P = 0.022). The histological grade of non-mass-type breast cancer with DCIS was significantly higher than that of mass-type breast cancer (P = 0.000). The histological grade of the former invasive ductal carcinoma was significantly lower than that of the latter (P = 0.006). Conclusion Non-mass breast cancer is more likely to occur in young people. Massive breast cancer is more likely to occur in middle-aged and elderly people. Non-bulky breast cancer was significantly associated with the presence of DCIS, but invasive ductal carcinoma tissue histological grade is relatively low, the degree of malignancy is not necessarily worse than mass-type breast cancer.