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报道一例男性69岁因头颈部复发性鳞癌应用顺铂200mg/m~2/1hr输注于48小时后发生双侧极度耳聋的病人。测听显示250～2000Hz听力损失75～100dB,2000Hz以上高频损失超过100dB。两周后复查听力无变化。作者复习有关顺铂耳毒性的文献,表明顺铂的耳毒性与氨基糖甙类相似,与最高血清值有关,大剂量输注可增加发病。认为在病人接受超过100mg/m~2剂量而在较长时间输入,则发生耳
Reported a male 69-year-old head and neck recurrent squamous cell carcinoma with cisplatin 200mg / m ~ 2 / 1hr infusion occurred 48 hours after bilateral extreme deafness patients. Audiometry shows 75 ~ 100dB hearing loss of 250 ~ 2000Hz, high frequency loss of more than 100Hz over 2000Hz. Two weeks after the review of hearing no change. The authors reviewed the literature on cisplatin ototoxicity, indicating that cisplatin ototoxicity and aminoglycosides similar to the highest serum value, high-dose infusion can increase the incidence. That the patient receives more than 100mg / m ~ 2 dose and enter a longer time, then the ear