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目的:研究泼尼松与环磷酰胺(CTX)联合治疗弥漫性间质性肺疾病(DILD)的疗效。方法:收集2012年1月~2016年1月我院收治的DILD患者120例,随机分为A组、B组、C组,每组40例。A组予以CTX治疗,B组予以泼尼松治疗,C组予以泼尼松联合CTX治疗,对比3组的疗效。结果:C组总有效率为87.50%,显著高于A组的62.50%和B组的65.00%(P<0.05);治疗后C组的临床-影像-生理评分(CRP评分)及圣·乔治呼吸问卷(SGRQ)评分显著低于A组和B组(P<0.05);治疗后C组的血清TNF-α及IL-6水平显著低于A组及B组(P<0.05);C组的肺功能指标较A组及B组显著改善(P<0.05)。结论:泼尼松联合CTX治疗DILD能够缓解临床症状、控制炎症反应、改善肺功能,疗效优于单用泼尼松或CTX。
Objective: To study the efficacy of prednisone combined with cyclophosphamide (CTX) in the treatment of diffuse interstitial lung disease (DILD). Methods: 120 cases of DILD admitted to our hospital from January 2012 to January 2016 were randomly divided into A group, B group and C group, 40 cases in each group. Group A received CTX treatment, Group B received prednisone, Group C received prednisone combined with CTX, compared the efficacy of three groups. Results: The total effective rate was 87.50% in group C, significantly higher than 62.50% in group A and 65.00% in group B (P <0.05). After treatment, the clinical-imaging-physiologic score (CRP) The level of serum TNF-α and IL-6 in group C were significantly lower than those in group A and group B (P <0.05), and the score of SGRQ in group C was significantly lower than that of group A and B (P <0.05) The lung function index was significantly improved compared with group A and group B (P <0.05). CONCLUSION: Prednisone and CTX treatment of DILD can relieve clinical symptoms, control inflammatory response and improve pulmonary function. The effect is superior to prednisone or CTX alone.