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目的:探讨高危肺动脉栓塞患者进行肺动脉内血栓抽吸联合溶栓治疗的疗效及安全性。方法:选取2012年5月~2017年5月我院收治的高危肺动脉栓塞患者18例,经肺动脉内导管抽吸和局部瑞替普酶溶栓的综合介入治疗,观察治疗前后临床症状改善情况及安全性。结果:18例术前平均动脉血氧分压、收缩压、呼吸频率、心率与术后12h比较均有统计学意义(P<0.05)。随访3-36个月,18例均疗效持续。结论:肺动脉内血栓抽吸联合局部瑞替普酶溶栓的治疗方法能迅速改善高危肺栓塞患者临床症状,改善患者预后。
Objective: To investigate the efficacy and safety of pulmonary thromboembolism and thrombolytic therapy in patients with high-risk pulmonary embolism. Methods: From May 2012 to May 2017, 18 cases of high-risk pulmonary embolism admitted to our hospital from January 2012 to December 2017 were enrolled in this study. The improvement of clinical symptoms were observed by comprehensive interventional therapy of pulmonary artery catheterization and local reteplase thrombolysis safety. Results: The mean preoperative arterial oxygen tension, systolic blood pressure, respiratory rate and heart rate were significantly different from those before operation (P <0.05). All the patients were followed up for 3-36 months, 18 cases were sustained effect. Conclusion: Pulmonary thrombus aspiration combined with local reteplase thrombolysis can rapidly improve clinical symptoms and improve prognosis of patients with high risk pulmonary embolism.