论文部分内容阅读
移植物抗宿主病(GVHD)是骨髓移植广泛用于临床治疗血液病的主要障碍,也是移植免疫学中一个复杂的问题。人们基于动物实验研究推测人类GVHD是骨髓中T淋巴细胞识别宿主的组织抗原差异,介导对宿主靶细胞和器官的免疫损伤。然而,由于人体系统实验的限制和缺乏对非HLA抗原免疫反应的敏感的体外检测方法,对于临床GVHD所表现出的免疫缺陷、免疫失调及自身免疫的免疫学机理尚未澄清。本文综述这方面的有关进展。 HLA与GVHD 在人的细胞第六对染色体上,存在着人类白细胞抗原(HLA)的两类抗原位点,Ⅰ类:HLA-A、
Graft-versus-host disease (GVHD) is a major obstacle to the widespread use of bone marrow transplantation in the treatment of hematological diseases and is a complex problem in transplant immunology. Based on animal experimental studies, it is speculated that human GVHD is a tissue antigen difference in the host of T lymphocyte recognition in bone marrow, and mediates immune damage to host target cells and organs. However, the immunological mechanisms of immunodeficiency, immune disorders and autoimmunity demonstrated by clinical GVHD have not yet been clarified due to the limitations of human system experiments and the lack of sensitive in vitro detection methods for immune responses against non-HLA antigens. This article summarizes relevant developments in this area. HLA and GVHD There are two types of human leukocyte antigen (HLA) epitopes on the sixth chromosome of human cell. Class I: HLA-A,