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长期和/或大量饮酒可引起酒精性肝损伤即酒精性肝病(alcoholic liver disease,ALD),虽然ALD的发生与酒精消耗的剂量和饮酒时间有关,且其进展有显著的特点,但目前还没有一个标准化的ALD动物模型,即缺乏与人类ALD完全类似的动物模型。而良好的实验动物模型对于探讨ALD的发病机制、筛选保肝药物以及预防和治疗方面等均有其重要意义,所以发展一个有效准确的ALD动物模型势在必行。目
Long-term and / or heavy alcohol consumption can cause alcoholic liver injury, ie, alcoholic liver disease (ALD). Although the incidence of ALD is related to the dose of alcohol consumption and alcohol consumption, and its progress is notable, there is not A standardized animal model of ALD, the lack of an animal model completely similar to human ALD. However, good experimental animal models are of great significance for exploring the pathogenesis of ALD, screening hepatoprotective drugs and preventing and treating the disease, so it is imperative to develop an effective and accurate ALD animal model. Head