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1985年 De Bold 和松尾等人从大鼠和人的心房分离出一类有排钠利尿作用的多肽,这类多肽总称为心房钠利尿肽(ANP)。从人类心房分离出来的多肽简称为 h-ANP。ANP 作为心脏分泌的激素和中枢及末梢神经系统的生理及病理生理意义引人关注。一、ANP 的结构和种类寒川和松尾从人的心房组织提取了 ANP,从中分离出分子量为3000的α-hANP,分子量为6000的β-hANP 和分子量为13000的γ-hANP,并全部确定了氨基酸结构,α-hANP 是含有二硫键结合的28个氨基酸的多肽,γ-hANP 由126个氨基酸组成,其 C 端具
In 1985, De Bold and Matsuo et al. Isolated a class of polypeptides that possess the effect of excretion of natriuretic peptides from the atria of rats and humans. These polypeptides are collectively referred to as atrial natriuretic peptide (ANP). The polypeptide isolated from the human atrium is abbreviated as h-ANP. ANP as a hormone secreted by the heart and the central and peripheral nervous system physiological and pathophysiological significance of concern. First, the structure and type of ANP Hanchuan and Matsuo extracted from human atrial tissue ANP, isolated from the molecular weight of 3000 α-hANP, molecular weight of 6000 β-hANP and molecular weight of 13000 γ-hANP, and all identified Amino acid structure, α-hANP is a disulfide-bonded 28 amino acid polypeptide, γ-hANP by 126 amino acids, the C-terminal