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目的：研究脑缺血／再灌后［３Ｈ］ＧＡＢＡ通过大鼠血脑屏障的外排转运是否增强及其机制．方法：将［３Ｈ］ＧＡＢＡ或ＧＡＢＡ（或丙磺舒）与其联合注射到缺血／再灌大鼠大脑皮层顶二区后，测定［３Ｈ］ＧＡＢＡ的脑外排指数（ＢＥＩ）及ｉｖ依文思蓝（ＥＢ）后ＥＢ的脑摄取量．结果：１０ｍｉｎ缺血／再灌３０ｍｉｎ、２ｈ、６ｈ和２４ｈ大鼠的ＢＥＩ分别为６７％，８３％，９２％和８７％，显著高于对照值（５８％），ＥＢ脑摄取量也显著增加；ＧＡＢＡ或丙磺舒明显降低正常及再灌６ｈ大鼠的ＢＥＩ，但对再灌５ｍｉｎ大鼠的ＢＥＩ无明显影响．结论：大鼠脑缺血／再灌后［３Ｈ］ＧＡＢＡ通过血脑屏障的外排转运显著增强．
OBJECTIVE: To study whether [3H] GABA enhances the efflux of blood-brain barrier through the rat brain and its mechanism after cerebral ischemia / reperfusion. METHODS: [3H] GABA or GABA (or probenecid) was injected into the top two regions of the cerebral cortex of ischemia / reperfusion rats to measure the brain effusion index (BEI) of [3H] GABA and iv Evans Brain EB uptake after blue (EB). RESULTS: The BEI of 10 min ischemia / reperfusion for 30 min, 2 h, 6 h and 24 h were 67%, 83%, 92% and 87%, significantly higher than that of the control (58% ; GABA or probenecid significantly reduced BEI in normal and reperfusion 6h rats, but had no significant effect on BEI in reperfusion rats for 5min. Conclusion: The efflux transport of [3H] GABA through the blood-brain barrier significantly increases after cerebral ischemia / reperfusion in rats.