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目的:观察柴胡疏肝散联合氟西汀治疗脑卒中后抑郁的临床疗效。方法:将80例脑卒中后抑郁患者按就诊顺序随机分为治疗组和对照组,每组40例,治疗组给予柴胡疏肝散联合氟西汀治疗,对照组给予氟西汀治疗,疗程均为4周,随访3个月,通过HAMD抑郁评估和临床神经功能缺损评分(MESSS)进行疗效评定。结果:治疗组抑郁显效率为50.0%,总有效率为95.0%,对照组抑郁显效率为35.0%,总有效率为80.0%;两组显效率和总有效率比较,差异均有统计学意义(P<0.05);治疗组神经功能康复总有效率为90.0%;对照组神经功能康复总有效率为75.0%,两组比较,差异有统计学意义(P<0.05);不良反应发生率治疗组为20.0%,对照组为35.0%,两组比较,差异有统计学意义(P<0.05)。结论:柴胡疏肝散联合氟西汀治疗脑卒中后抑郁疗效显著,副作用小。
Objective: To observe the clinical efficacy of Chaihu Shugan San combined with fluoxetine in the treatment of post-stroke depression. Methods: Eighty patients with post-stroke depression were randomly divided into treatment group and control group, with 40 cases in each group. The treatment group was treated with Chaihu Shugan San combined with fluoxetine and the control group with fluoxetine. The treatment course All patients were followed up for 3 months after 4 weeks. The curative effect was assessed by HAMD depression assessment and clinical neurological deficit score (MESSS). Results: The effective rate of depression in the treatment group was 50.0%, the total effective rate was 95.0%, the effective rate of depression in the control group was 35.0% and the total effective rate was 80.0%. The difference between the two groups was statistically significant (P0.05). The total effective rate of neurological rehabilitation was 90.0% in the treatment group and 75.0% in the control group. There was significant difference between the two groups (P0.05), and the incidence of adverse reactions Group was 20.0%, control group was 35.0%, the difference between the two groups was statistically significant (P <0.05). Conclusion: Chaihu Shugan San combined with fluoxetine has significant curative effect on post-stroke depression with little side effects.