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目的探讨非小细胞肺癌(Non-small cell lung cancer,NSCLC)组织中乳腺癌易感基因1(BRCA1)和原癌基因(C-Myc)的表达情况及临床意义。方法收集NSCLC患者组织标本48例和癌旁正常组织20例,采用免疫组化SP法检测各组中BRCA1和C-Myc的表达,应用统计学软件SPSS 16.0行数据处理,分析BRCA1与临床病理指标及C-Myc的关系。结果 NSCLC中BRCA1和C-Myc的表达率分别为58.33%(28/48)和68.75%(33/48)。两者阳性率明显高于癌旁组织(P<0.05);BRCA1异常表达与NSCLC的肿瘤分期(TNM)、有无淋巴结转移相关(P<0.05),与年龄、性别、组织类型、分化程度无显著性相关(P>0.05)。C-Myc阳性表达与NSCLC的分化程度、肿瘤分期(TNM)、有无淋巴结转移相关(P<0.05),与年龄、性别无显著性相关(P>0.05)。通过相关性分析得出BRCA1和C-Myc的表达存在显著相关性(P<0.05)。结论 BRCA1和C-Myc在NSCLC发生和转移中可能起重要作用,BRCA1和C-Myc与NSCLC的浸润转移密切相关,可作为预后的判断指标。
Objective To investigate the expression and clinical significance of BRCA1 and C-Myc in non-small cell lung cancer (NSCLC). Methods The expression of BRCA1 and C-Myc in each group were detected by immunohistochemical SP method in 48 cases of NSCLC patients and 20 cases of adjacent normal tissue. Statistical analysis software SPSS 16.0 was used to analyze the relationship between BRCA1 and clinicopathological parameters And C-Myc relationship. Results The expression rates of BRCA1 and C-Myc in NSCLC were 58.33% (28/48) and 68.75% (33/48), respectively. (P <0.05). The abnormal expression of BRCA1 correlated with tumor stage (TNM) and lymph node metastasis (P <0.05) in NSCLC, but not with age, sex, histological type, degree of differentiation Significantly related (P> 0.05). The positive expression of C-Myc was correlated with the differentiation of NSCLC, TNM and lymph node metastasis (P <0.05), but not with age and sex (P> 0.05). Correlation analysis showed that there was a significant correlation between the expression of BRCA1 and C-Myc (P <0.05). Conclusions BRCA1 and C-Myc may play an important role in the carcinogenesis and metastasis of NSCLC. The expression of BRCA1 and C-Myc is closely related to the infiltration and metastasis of NSCLC and may be used as a prognostic indicator.