Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cel

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：jpy_2008

【摘要】

：

【作者】

：

Minhee Jang Min Jung Lee Ik-Hyun Cho

【机构】

：

Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 1

【出处】

：

The 18th Congress of the International Federation of Associa

【发表日期】

：

2014年8期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

The potential neuroprotective value of ethyl pyruvate (EP) for the treatment of the striatal toxicity is largely unknown.We investigated whether EP promotes the survival of striatal neurons in a 3-nitropropionic acid (3-NP)-induced mouse model of Huntingtons disease (HD).EP (5, 10, 20, and 40 mg/kg/day, i.p.) was daily injected from 30 minutes before 3-NP intoxication (pretreatment) and from onset/progression/peak point of neurological impairment by 3-NP intoxication.

其他文献

From the description of the thalamus made by dejerine to terminologia anatomica

The purpose of the study was to review various terminologies related to the description of the thalamic nuclei, from the one provided by Dejerine and Roussy in 1906 to describe the Dejerine-Roussy syn

会议

Functional evaluation of the relation between the pituitary gland, cavernous sinus and internal caro

This study deals with the relations between the pituitary (PG),cavernous sinus (CS) and internal carotid artery (ICA), by means of morphometric measurements on MRI and CT images from 8 males (M) and 8

会议

The local circuit in the cerebral cortex: Information processing and dynamical systems

In spite of recent progress in brain sciences, the local circuit of the cerebral neocortex still remains elusive.Morphological works on excitatory cortical circuitry from thalamocortical (TC) afferent

会议

Alterations in the neural circuits from peripheral afferents to the spinal cord: Possible implicatio

Diabetic polyneuropathy (DPN) presents as a wide variety of sensorimotor symptoms.Changes in the neural circuits may occur in the early stages in diabetes and are implicated in the development of DPN.

会议

The contribution of innate immune response on synaptic physiology and cognitive function after traum

Traumatic brain injury has been consistently linked with increased risk of multiple neurodegenerative diseases including dementia.Recent work with surviving patients,post-mortem tissue samples, as wel

会议

MRI anatomy of the hypoglossal nerve correlated with cyosectional specimen and its possible neurosur

To study the sectional anatomy of the hypoglossal nerve using MRI correlated with cryosectional sections for providing anatomic data for neurosurgery.MR images were obtained from 34 adult volunteers e

会议

Progression of mitochondria and endoplasmic reticulum changes following kaolin induced hydrocephalus

Mitochondria and endoplasmic reticulum are important for neuronal function.The severity and progression of morphological anomalies of these organelles in hydrocephalus have not been extensively studie

会议

Neural networks in classification scheme of neurons from the adult

This study applies neural networks to both type of neuron classification, quantitative and morphological and determine whether the neurons of human dentate nucleus can be classified on four morphologi

会议

A comparative study on the effects of type Ⅰ and type Ⅱ diabetes on learning and memory deficit and

In addition to learning and memory impairments, diabetes may also brings about neuronal loss in different regions of the brain specially hippocampus.In this line, the present study was conducted to in

会议

Propidium iodide (PI), a new candidate for Nissl body staining under the fluorescence microscope

Propidium iodide (PI), as a common fluorescent dye, is usually used for nucleic acids staining, which can react with both RNAs and DNAs.The PI positive signals in the nuclei are normally stronger than

会议

Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cel

其他学术论文