【摘 要】
：
Aberrant human leukocyte antigen-G (HLA-G) expression is associated with tumor invasiveness and poor clinical prognosis, but the mechanisms remain unknown.In this study, we found that matrix metallopr
【机 构】
：
Wenzhou Medical College China
【出 处】
：
BIT`s 1st International Congress of Gynaecology and Obstetri
论文部分内容阅读
Aberrant human leukocyte antigen-G (HLA-G) expression is associated with tumor invasiveness and poor clinical prognosis, but the mechanisms remain unknown.In this study, we found that matrix metalloproteinase-15 (MMP-15) expression was up-regulated in an ovarian carcinoma cell line (HO-8910) engineered to express HLA-G (HO-8910-G).Consistent with this, a strong correlation between HLA-G and MMP-15 expression were observed in a cohort of ovarian cancer samples.HO-8910-G cells are of strong migration and invasion potential compared with the parental HO-8910 cells and expressed high level of MMP-15.Multi-cellular spheroid formation exists only in HO-8910-G cells.In Balb/c nu/nu mouse model, widespread metastasis was observed in mice xenografted with HO-8910-G cells, but not in the group with parental cells.Mouse survival was dramatically decreased in HO-8910-G xenografted mice than that with HO-8910 cells.Knockdown the induced MMP-15 expression by small interfere RNA (siRNA) significantly decreased the HO-8910-G cell migration, spheroid formation and invasion potential and tumor metastasis;however, significantly increased the mouse survival.Collectively, this is the first evidence that HLA-G expression is associated with poor survival in an animal model, and HLA-G correlated with tumor invasiveness or metastasis may rely on the induction of MMP-15 expression in ovarian cancer.
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