【摘 要】
：
This study was presented at the American College of Obstetricians and Gynecologists 55th Annual Clinical Meeting San Diego California May 5-9, 2007 and published in Reproductive BioMedicine Online 201
【机 构】
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Cornell University USA
【出 处】
：
BIT`s 1st International Congress of Gynaecology and Obstetri
论文部分内容阅读
This study was presented at the American College of Obstetricians and Gynecologists 55th Annual Clinical Meeting San Diego California May 5-9, 2007 and published in Reproductive BioMedicine Online 2010 20, 675-680.PCOS is considered one of the most common endocrine disorders impacting women of reproductive age.Abnormalities of inhibin secretion have long been postulated in the pathogenesis of polycystic ovarian syndrome (PCOS).Inhibin A, a 31 kD disulphide-linked heterodimeric protein hormone, was measured.The test is based on the two subunit-specific antibodies enzyme-linked immunosorbent assay (ELISA) method..The stability of inhibin an inserum samples over time has been demonstrated previously..A prospective case-series was performed to determine whether there is a relationship between polycystic of PCOS and ethnicity.Also, serum inhibin A concentrations were compared between PCOS and normal-ovulatory women.The possibility of a correlation between inhibin A, androgens and insulin resistance in PCOS women was evaluated.Inhibin A concentrations were significantly lower (4.5 ± 4.8 pg/ml) when compared with the control group (13.2 ± 14.4 pg/ml;P =0.003) and were not significantly different between Hispanic and Caucasian women diagnosed with PCOS.There was no correlation between inhibin a concentrations and insulin, testosterone, free testosterone, 17-OHP, or DHEAS concentrations.In PCOS women, inhibin concentrations are similar between Hispanic and Caucasian women;however, women with PCOS, regardless of ethnicity, have a lower inhibin.A concentration compared with normal-ovulatory women.No correlation was observed between inhibin A androgens and insulin resistance in women diagnosed.Further large-scale studies are needed to validate the findings presented here.
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