【摘 要】
：
TP53 gene mutation is the most frequent alteration in ovarian carcinomas; TP53 accumulation in tumor cells usually reflects a TP53 gene missense mutation.TP53 is a transcriptional factor with pleiotro
【机 构】
：
Department of Pathology Institute of Oncology Poland
【出 处】
：
2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
TP53 gene mutation is the most frequent alteration in ovarian carcinomas; TP53 accumulation in tumor cells usually reflects a TP53 gene missense mutation.TP53 is a transcriptional factor with pleiotropic activity, regulating the expression of many proteins.Biochemical and biological data suggest that cells with impaired TP53 may be biologically different from those with wild type TP53 (a permissive environment for action of oncogenes versus a rate limiting one).We evaluated clinical significance of TP53 and other proteins (detected by immunohistochemistry) in ovarian carcinomas from 432 patients treated with platinum-based regimens (PC/PAC, n=233) or with taxol and cisplatin (TP, n=199).Statistical analyses were performed in all patients, and separately in the group with (TP53+) and without tumor TP53 accumulation (TP53-).Predictive and/or prognostic significance of several proteins (BCL-2, ERBB2, survivin) was seen either in the TP53(-) or TP53(+) group only, and not in all patients.Our results suggest that binomial TP53 status divides ovarian carcinomas into two biologically distinct groups that differ in prognostic and predictive factors.Thus, TP53(+) and TP53(-) ovarian carcinomas should be considered as separate entities in clinical studies.This may allow for more successful identification of molecular targets for clinical treatment (the KBN grants 4P05C 028 14 and 2P05A 068 27).
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