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  5. Generation of Rm21LG transgenic mice: a powerful tool to generate conditional overexpression of miR-

Generation of Rm21LG transgenic mice: a powerful tool to generate conditional overexpression of miR-

来源 :2016华南实验动物科学国际研讨会、第三届实验小型猪国际论坛暨广东·九州实验动物学术交流会 | 被引量 : 0次 | 上传用户：nbywfcom
【摘 要】
：
miR-21 is highly expressed in a variety of cancers,suggesting that it might play a role in the process of oncogenesis,as supported by it directly causing pre-B cell lymphomas in transgenic mice.Rm21LG
【作 者】
：
Tao Du Junshuang Jia Xiaolin Lin Raoying Xie Jing Li Dong Xiao Kang Xu 
【出 处】
：
2016华南实验动物科学国际研讨会、第三届实验小型猪国际论坛暨广东·九州实验动物学术交流会
【发表日期】
：
2016年10期
【关键词】
：
Cancer prevention Conditional gene expression Cre/lox P system miR-21 Oncogenesi 
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　　miR-21 is highly expressed in a variety of cancers,suggesting that it might play a role in the process of oncogenesis,as supported by it directly causing pre-B cell lymphomas in transgenic mice.Rm21LG transgenic mice for the conditional co-expression of rniR-21 and luciferase (Luc) mediated by Cre/lox P system were generated.The homozygous Rm21LG transgenic mice were visually and readily characterized immediately after birth by whole-body fluorescence imaging.
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