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Increasing evidence suggests that the renin-angiotensin system (RAS) plays an important role in tumorigenesis.The interaction between Angiotensin Ⅱ (AngⅡ) and angiotensin type 1 receptor (AT1R) may have a pivotal role in hepatocellular carcinoma (HCC) and therefore,AT1R blocker and angiotensin I-converting enzyme (ACE) inhibitors may have therapeutic potential in the treatment of hepatic cancer.Although the involvement of AT1R has been well explored,the role of the angiotensin Ⅱ Type 2 receptor (AT2R) in HCC progression remains poorly understood.Thus,the aim of this study was to explore the effects of AT2R overexpression on HCC cells in vitro and in mouse models of human HCC.An AT2R recombinant adenoviral vector (Ad-G-AT2R-EGFP) was transduced into HCC cell lines and orthotopic tumor grafts.