Adiponectin induced AMPK impairment mediates Insulin Resistance in Bama mini-pig fed High-fat and Hi

来源 :2016华南实验动物科学国际研讨会、第三届实验小型猪国际论坛暨广东·九州实验动物学术交流会 | 被引量 : 0次 | 上传用户:ab869
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  Aims/Introduction: Adipose tissue is no longer considered as an inert storage organ for lipid,but instead is thought to play an active role in regulating insulin effects via secretion adipokines.However,conflicting reports have emerged regarding the effects of adipokines.In this study,we investigated the role ofadipokines in glucose metabolism and insulin sensitivity in obese Bama mini-pigs.Materials and Methods: An obesity model was established in Bama mini-pigs,by feeding with high-fat and high-sucrose diet for 30 weeks.Plasma glucose and blood biochemistry levels were measured,and intravenous glucose tolerance test was performed.
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