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  5. ERK pathway involved in pulmonary vascular endothelial cell apoptosis induced by cigarette smoke ext

ERK pathway involved in pulmonary vascular endothelial cell apoptosis induced by cigarette smoke ext

来源 :第十二届中青年呼吸学者论坛 | 被引量 : 0次 | 上传用户：keaiyuyu66
【摘 要】
：
Background: Recent reports indicate that DNA methylation is regulated in part by the ERK pathway,and that ERK pathway is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).Ou
【作 者】
：
Zong Dandan Chen Ping Ouyang Ruoyun 
【机 构】
：
Department of Respiratory Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hun
【出 处】
：
第十二届中青年呼吸学者论坛
【发表日期】
：
2015年11期
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Background: Recent reports indicate that DNA methylation is regulated in part by the ERK pathway,and that ERK pathway is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).Our previous study has confirmed that mitochondrial transcription factor A (mtTFA)aberrant methylation participated in pulmonary vascular endothelial cells apoptosis in COPD.The aim of the present study was to investigate the role of ERK in pulmonary vascular endothelial cell apoptosis induced by cigarette smoke extract (CSE) and underlying mechanisms.
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