【摘 要】
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Apeiron Biologics is a small Biotech company engaged in the development of innovative therapeutics based on validated targets derived from biomedical break-through discoveries.We are developing an Ang
【机 构】
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Research and Development Apeiron Biologics Austria
【出 处】
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2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Apeiron Biologics is a small Biotech company engaged in the development of innovative therapeutics based on validated targets derived from biomedical break-through discoveries.We are developing an Angiotensin Converting Enzyme 2 (ACE2) based enzyme substitution therapy to treat acute lung,kidney,liver and heart diseases.ACE2 is an essential enzyme of the Renin Angiotensin system,which is down-regulated in multiple acute and life threatening indications.We have established an industrial and scalable CHO based production process to generate highly soluble,fully active,complex N-glycosylated recombinant,human soluble ACE2.This purpose was achieved by a comprehensive clone selection strategy including productivity and product quality analysis at each selection round,as well as also intracellular FACS,activity and N-glycosylation analysis.A suitable pharmacology profile together with confirmed therapeutic effects in ARDS will enable us to initiate our clinical development program in the next moths.
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