【摘 要】
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OBJECTIVE: The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by both melatonin and serotonin.Agomelatine, which acts as an antidepressa
【机 构】
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Department of Physiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, PR
【出 处】
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2015年中国中西医结合学会时间生物医学专业委员会学术研讨暨换届会议
论文部分内容阅读
OBJECTIVE: The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by both melatonin and serotonin.Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic MT1 and MT2 agonist and serotonergic 5-HT2C antagonist properties.
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