PON2 and ATP2B2 Gene Polymorphisms with Noise-Induced Hearing Loss

• 作 者: XiutingLi[1]JinglianCao[2]JunWang[3]HaiyanSong[4]GuizhuWang[4]GuixiangJi[5]QiuDong[4]ChunlongWei[4]YingCao[6]BoshenWang[7]BaoliZhu[7]HangXiao[3]
• 机 构: Key Lab of Modem Toxicology,Ministry of Education. Department of Toxicology,School of Public Health,
• 出 处: 中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛
• 发表日期: 2015年期

　　Background: Noise-induced Hearing Loss (NIHL)is a complex disease and induced by a combination of genetic and environmental factors.PON2 gene(Paraoxonase2), involved in the regulation of reactive oxygen species and affecting the vulnerability of the cochlea to NIHL, and A TP2B2 gene(ATPase, calcium-transporting, plasma membrane 2) which encodes plasma membrane calcium-transporting ATPase isoform 2 (PMCA2) are the candidate genes relating to the attack of NIHL.In this study, we investigated whether ATP2B2 and PON2 polymorphisms were associated with NIHL in Chinese Han population.