DNA demethylation confers competence on the genome for zygotic genome activation in zebrafish embryo

来源 :第三届“模式生物与人类健康”发育遗传学全国学术研讨会 | 被引量 : 0次 | 上传用户：AAA0662AAA

【摘要】

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The zygotic genome of animal embryos is transcriptionally inactive upon fertilization,and becomes active after a certain period of development.As transcription

【作者】

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Anming Meng

【机构】

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State-KeyLaboratoryofBiomembraneandMembraneEngineering,Tsinghua-PekingCenterforLifeSciences,Schoolof

【出处】

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第三届“模式生物与人类健康”发育遗传学全国学术研讨会

【发表日期】

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2014年7期

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The zygotic genome of animal embryos is transcriptionally inactive upon fertilization,and becomes active after a certain period of development.As transcription can be controlled by the presence of 5-methylcytosines (5mC) in DNA,the global DNA methylation level in an embryo may play a role in the zygotic genome activation (ZGA).In mammals,the paternal genome is rapidly demethylated immediately after fertilization through 5mC hydroxymethylation,resulting in a decrease of the global DNA methylation level of the zygote genome.

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DNA demethylation confers competence on the genome for zygotic genome activation in zebrafish embryo

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