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Stable infection with herpesviruses such as EBV and KSHV depends on the ability to tether their episome to the host chromatin to prevent dilution over serial cell divisions.Disruption of this link would interfere with infection and, thus, has obvious therapeutic implications.For KSHV, this tether comprises a series of homodimers of the virally encoded latency-associated nuclear antigen (LANA).These dimers bind with their C-termini to a pair of specific sequences in the terminal repeat (TR) region of the viral episome and with their N-termini to host nucleosomes.