TAR DNA binding protein of 43 kDa (TDP-43) is a major deposited protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ub
Ataxin-7 (Atx7) is a subunit of the DUB module (DUBm), which is a component of the mammalian STAGA transcription coactivator complex.Its polyglutamine (Poly
Huntingtons disease (HD) is a progressive neurodegenerative disorder of the central nervous system, which is caused by the polyglutamine (polyQ) expansion i
NEDD8 is a ubiquitin-like protein which regulates pivotal biological processes by conjugating to client proteins.NEDD8 and neddylation are negatively regula
G-protein-coupled receptors (GPCRs) are the largest family of membrane protein and mediate most of the transmembrane signal transduction.Human chemokine rec
In contrast to a large number of work of water soluble proteins folding.Little is known about the structural properties of membrane proteins which is diffic
Proteins with an aberrant extension of polyglutamine (polyQ) are the main pathological causes of neurodegenerative polyglutamine diseases.Among these, spino
In proteins, conformational change impacting biological function has been well-investigated in the past decades, which has been generally named allosteric e