Cytoplasmic USP19 regulates polyglutamine-expanded proteins through an HSP90 chaperone complex

来源 :2013年第四届全国“跨学科蛋白质研究”学术讨论会 | 被引量 : 0次 | 上传用户：julian

【摘要】

：

　　Proteins with an aberrant extension of polyglutamine (polyQ) are the main pathological causes of neurodegenerative polyglutamine diseases.Among these, spino

【作者】

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郑学明何文天张宇航郜永光宋爱新 Fran(c)oise Gisou van der Goot 胡红雨

【机构】

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中国科学院上海生命科学研究院生物化学与细胞生物学研究所,分子生物学国家重点实验室,上海200031GlobalHealthInstitute,EcolePolytechniqueFédéraledeL

【出处】

：

2013年第四届全国“跨学科蛋白质研究”学术讨论会

【发表日期】

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2013年10期

【关键词】

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USP19 HSP90 ataxin-3 polyQ aggregation CHIP SCA3

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　　Proteins with an aberrant extension of polyglutamine (polyQ) are the main pathological causes of neurodegenerative polyglutamine diseases.Among these, spinocerebellar ataxia type-3 (SCA3) is caused by polyQ-expansion of ataxin-3 (Atx3).

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Cytoplasmic USP19 regulates polyglutamine-expanded proteins through an HSP90 chaperone complex

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