The heat-shock protein DegP is essential for the survival of Escherichia coli cells at elevated temperatures.Substrate binding transforms hexameric DegP int
Diabetes shows deregulated coordination of glucose production and utilization.Mechanisms underline metabolic homeostasis coordination remains elusive.We fou
目前认为内质网巯基氧化酶Ero1/蛋白质二硫键异构酶PDI通路是真核生物负责蛋白质氧化折叠的主要通路。相比于低等真核生物(如酵母),高等真核生物(如人)合成数量和种类更多
Peroxiredoxin 4(Prx4)是Prx过氧化物酶家族中唯一定位于内质网中的成员.Prx4在清除内质网自由基H2O2的同时可以通过氧化蛋白质二硫键异构酶(PDI)催化底物蛋白中二硫键的
蛋白质二硫键异构酶(protein disulfide isomerase,PDI)是参与内质网蛋白质氧化折叠的关键分子,由四个硫氧还蛋白结构域(a,b,b和a),b和a间的柔性区域x-linker以及富含酸
Fatty acid binding protein 4 (FABP4) is a potential drug target for diabetes and atherosclerosis.In this work, virtual screening approach was applied in ord
Isogarcinol the bioactive polyisoprenylated benzophenone derivative was isolated from Garcinia mangostana L..In our previous study, and exerted a strong inh
在人细胞内质网中,蛋白质二硫键异构酶PDI和巯基氧化酶Ero1α构成主要的氧化折叠途径:Ero1α利用分子氧氧化PDI,氧化态的PDI进而催化底物的二硫键形成.Ero1α的活力受到其
In tumor microenvironment, innate immune cells, especially macrophages smoulder inflammation and serve a very important role in tumor growth and metastasis.
本文介绍了一台纳秒脉冲升温时间分辨中红外光谱仪,可以实现对蛋白质二级结构的瞬态光谱测量。该光谱仪采用高稳定性的CO连续激光作为探测光源。新搭建的CO激光器出光波