巨噬细胞盐皮质激素受体敲除抑制小鼠动脉粥样硬化

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：djmaxha

【摘要】

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目的:动脉粥样硬化疾病是导致人类死亡的主要原因之一.类固醇激素醛固酮与心血管疾病死亡率直接相关,在此疾病中起重要作用.醛固酮作用受体(盐皮质激素受体)拮抗剂可治疗心衰

【作者】

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沈竹夏孙雪楠施焕敬张嘉伟郑晓君张武昌刘明珠段胜仲

【机构】

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中国科学院上海生命科学研究院营养科学研究所

【出处】

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2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

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2014年10期

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目的:动脉粥样硬化疾病是导致人类死亡的主要原因之一.类固醇激素醛固酮与心血管疾病死亡率直接相关,在此疾病中起重要作用.醛固酮作用受体(盐皮质激素受体)拮抗剂可治疗心衰并减少心血管疾病死亡率,且具有治疗动脉粥样硬化疾病的潜力.动物实验表明MR在动脉粥样硬化中具有重要作用,但其细胞与分子机制尚不完全明确.我们将研究巨噬细胞MR对小鼠动脉粥样硬化的调控机制.

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巨噬细胞盐皮质激素受体敲除抑制小鼠动脉粥样硬化

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