TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang Ⅱ induced v

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：tomato20099002

【摘要】

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TMEM 16A protein is recently identified as an important component of Ca+-dependent Cl-channels (CaCCs) in vascular smooth muscle cells (VSMCs).However, the func

【作者】

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Xin-hua Zhang Bin Zheng Jin-kun Wen

【机构】

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DepartmentofBiochemistryandMolecularBiology,KeyLaboratoryofNeuralandVascularBiology,MinistryofEducat

【出处】

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2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

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2014年10期

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TMEM 16A protein is recently identified as an important component of Ca+-dependent Cl-channels (CaCCs) in vascular smooth muscle cells (VSMCs).However, the functions of TMEM16A protein and the mechanisms responsible for regulating TMEM16A gene expression in the vessels remain largely unclear.Here we showed that myocardin activated TMEM 16A expression by forming a complex with SRF bound to the CArG of the TMEM 16A promoter in VSMCs.

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TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang Ⅱ induced v

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