Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blocking positive feedb

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：tanya1005

【摘要】

：

Tongxinluo (TXL), a traditional Chinese medicine, has multiple vasoprotective effects including anti-inflammation.MicroRNA-155 (miR-155) is involved in vascular

【作者】

：

Ruo-nan Zhang Bin Zheng Jin-kun Wen

【机构】

：

DepartmentofBiochemistryandMolecularBiology,KeyLaboratoryofNeuralandVascularBiology,MinistryofEducat

【出处】

：

2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

：

2014年10期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Tongxinluo (TXL), a traditional Chinese medicine, has multiple vasoprotective effects including anti-inflammation.MicroRNA-155 (miR-155) is involved in vascular inflammation and atherosclerosis.However, a direct relationship between TXL and miR-155 in the development of vascular inflammation and remodeling had not yet been shown.The objective of the present study was to investigate whether TXL exerts an inhibitory effect on the vascular inflammatory response and neointima hyperplasia by regulating miR-155 expression.

其他文献

The reduced LCAT level and activity in Hepatitis B virus carriers as a possible cause of a low level

BACKGROUND: Increased prevalence of atherosclerosis in Hepatitis B virus (HBV) carriers is possibly due to low levels of high density lipoprotein cholesterol (H

会议

Apelin ameliorates myocardial insulin resistance and improves myocardial injury in diabetes

Background: Apelin as a beneficial adipokine has been linked to insulin resistance and cardiovascular protection in diabetes;however, the underlying molecular m

会议

MiR-301a Mediates the Effect of IL-6 on the AKTGSK Pathway and Hepatic Glycogenesis by Regulating PT

Objective: IL-6 has been implicated in the pathogenesis of insulin resistance.MiR-301 a plays an important role in various biological and pathological processes

会议

miR-291b-3p在肝脏脂质代谢中的作用机制研究

目的:miR-291 b-3p是miR-290家族中的一员,在胚胎发育过程中起重要作用,而在脂代谢中的作用尚未见报道,本研究旨在阐明其在肝脏脂质代谢中的作用及其机制.方法:首先在NCTC 14

会议

High Levels of Pigment Epithelium-derived Factor in Diabetes Impair Wound Healing through Suppressio

Diabetic foot ulcer (DFU), caused by impaired wound healing, is a common vascular complication of diabetes.However, the pathogenesis of wound healing deficiency

会议

Calculus bovis cultivated by glucuronidase attenuates atherosclerotic plaque development in apolipop

Objective: In this study we aim to examine the effects of Calculus Bovis cultivated by Glucuronidase (CBCG), in vitro cultured substitute of natural Calculus Bo

会议

Human hepatoma (HCC) has been reported to be strongly resistant to Fas-mediated apoptosis.However, the underlying mechanisms are poorly understood.In this study

会议

MicroRNA-16 represses myocardial hypertrophy by inhibiting CCND1, CCND2 and CCNE1 expression in card

Aims: Cell-cycle regulatory proteinsand microRNAs (miRs) play important roles in cardiomyocyte hypertrophy, but it remains largely unknown how both coordinate d

会议

A Novel ATRA derivative N-(3-trifluoromethyl-phenyl)-retinamide (ATPR) inhibits lung adenocarcinoma

Objective: To observe the effects of a novel ATRA derivative ATPR on lung adenocarcinoma A549 cells and to explore the probable mechanism of ATPR inhibiting A54

会议

Calpastatin Prevents NFkB-Mediated Hyperactivation of Macrophages implications in foam cell formatio

Aims: Calpastatin (CAST), an endogenous calpain enzymes inhibitor, negatively regulates the cleavage of calpain targets and have been implicated in inflammatory

会议

Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blocking positive feedb

其他学术论文