【摘 要】
：
[Objective]To test that oyster crude polysaccharides (OPS) may alter the immune response in weanling piglets, we investigated whether OPS attenuates production of cytokines which induced by lipopolysa
【机 构】
：
Engineering Laboratory of Animal Pharmaceuticals & College of Animal Science,Fujian Agriculture and
【出 处】
：
中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会
论文部分内容阅读
[Objective]To test that oyster crude polysaccharides (OPS) may alter the immune response in weanling piglets, we investigated whether OPS attenuates production of cytokines which induced by lipopolysaccharide(LPS) and expression of PPARγ in weanling piglets.This study evaluated whether OPS attenuates LPS-induced immune stress in weanling piglets.[Method]Thirty healthy crossbred piglets (28 ± 1 days old) were randomly divided into 5 groups (6 piglets/group).Blank control and LPS-induced groups were fed with the basal diet.OPS groups were fed with the basal diet which supplemented with 0.5%, 0.8%, and 1.2% OPS for 30 days.LPS-induced group, as well as OPS groups were then injected intraperitoneally with LPS (100 μg/kg body weight), whereas the blank control group was given phosphate buffered saline.The concentrations of TNF-α, IL-1β and IL-6 in plasma were detected by ELISA.mRNA levels of PPARγin liver, spleen, adrenal gland and thymus in piglets were detected by qPCR.[Results]The results showed that compared with the blank control, LPS treatment significantly increased plasma IL-1β, IL-6 and TNF-α levels (P<0.05), which was significantly attenuated by supplementing 0.5%, 0.8% or 1.2% OPS in the diet.In addition, LPS significantly induced mRNA expression of PPARγin liver, spleen, adrenal gland, and thymus in piglets, which was blocked by adding OPS regardless of the doses.[Conclusion]These results indicate that dietary supplementation of OPS was able to alleviatethe immune stress induced by LPS.
其他文献
Rac1 is activated by DOCK5 which affect actin polymerization through PAK1, LIMK and Cofilin.It is confirmed that OPG (osteoprotegerin, OPG) have an effect on differentiation of osteoclasts, while its
The porcine epidemic diarrhea virus (PEDV) is an enveloped, single-stranded positive-sense RNA virus that causes porcine epidemic diarrhea (PED), an acute and highly contagious enteric disease in pigs
Twenty one-year-old local male dogs were randomly assigned into four groups (five dogs per group).The control and the ethylene glycol (EG) groups were fed basal diets without and with EG, and the EG+s
[Background] Selenium (Se) plays an important role in regulating various metabolic processes in the body.Se raised considerable expectations for the prevention of vascular disease, cancer, and other c
Porcine coronaviruses (CoVs) are major viral infectious diseases of swine.Examples of porcine CoVs include porcine transmissible gastroenteritis coronavirus (TGEV), porcine epidemic diarrhea virus (PE
This study aimed to investigate the effects of Se-enriched probiotics (SP) on the liver fibrosis induced by CCl4 in rats.The results showed that SP significantly decreased serum alanine aminotransfera
Lameness is a major issue influencing dairy cow health.Lameness in dairy cows not only causes loss of appetite, reduction of milk production and reproduction performance, and an increase of rejection
Bovine coronavirus (BCoV) causes severe diarrhea in newborn calves and respiratory tract infections in calves and feedlot cattle.Although rarely fatal, BCoV infection is associated with dramatic reduc
Bocaviruses have a broad mammalian host range including humans, cows, pigs, gorillas, chimpanzees,Californian sea lions, dogs, cats, bats, and pine martens.Bocavirus, a genus of the Parvovirinae subfa
The trichothecene deoxynivalenol (DON), a foodborne mycotoxin found in grain-based foods, has been associated with human and animal food poisoning.Although induction of anorexia has been described as