Organic selenium alleviated the formation of ethylene glycol-induced calcium oxalate renal calculi b

来源 :中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会 | 被引量 : 0次 | 上传用户:backaroo2
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  Twenty one-year-old local male dogs were randomly assigned into four groups (five dogs per group).The control and the ethylene glycol (EG) groups were fed basal diets without and with EG, and the EG+sodium selenite (EG+SS) and EG+selenium yeast (EG+SY) groups were fed basal diets with EG containing SS and SY,respectively.Blood, urine and renal samples were taken after 18 weeks of feeding.The results showed that compared with the control group, the serum calcium levels and antioxidase activities significantly decreased in the EG group.Serum creatinine, urea nitrogen and malondialdehyde (MDA) levels and urine calcium and oxalate levels significantly increased.Calcium oxalate crystal deposition and osteopontin (OPN) mRNA and protein expression in the renal tissues significantly increased.These changes above in the EG group were reversed within limits by adding selenium in the diets (both EG+SS and EG+SY groups).Further, compared with the EG+SS group, the EG+SY group showed better effects in decreasing the formation of EG-induced calcium oxalate renal calculi and OPN expression and improving antioxidant capability in dogs.It indicates that organic selenium has the potential value to alleviate the formation of EG-induced calcium oxalate renal calculi.
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