【摘 要】
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This study aimed to investigate the effects of Se-enriched probiotics (SP) on the liver fibrosis induced by CCl4 in rats.The results showed that SP significantly decreased serum alanine aminotransfera
【机 构】
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Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural
【出 处】
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中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会
论文部分内容阅读
This study aimed to investigate the effects of Se-enriched probiotics (SP) on the liver fibrosis induced by CCl4 in rats.The results showed that SP significantly decreased serum alanine aminotransferase (87.0±1.96) U/L,aspartate aminotransferase (101±3.13) U/L, hepatic hydroxyproline (898±72.5) μg/g and malondialdehyde (2.39±0.34) nmol/mg levels, but increased glutathione peroxidase (37.2 ± 3.19) U/mg, superoxide dismutase (201 ± 19.2) U/mg and glutathione levels (3.32±0.25) mg/g (P<0.05) in rats treated by CCl4.SP suppressed hepatic inflammation and necrosis induced by CCl4.Moreover, SP significantly reduced the expression of α-smooth muscle actin, collagen, TGF-β1, TIMP-1 and inflammation-related gene and induced apoptosis of activated hepatic stellate cells (P<0.05) in rats treated by CCl4.Our results suggest that SP could protect the liver fibrosis by attenuating hepatic oxidative stress, suppressing hepatic inflammation and inducing apoptosis of hepatic stellate cells.
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