【摘 要】
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FBXW7 is a general tumor suppressor and its mutations have been found in a variety of human cancers.Particularly, FBXW7 mutations occur in nearly 10-15% of colorectal cancer (CRC), ranking it the four
【机 构】
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University College London UK
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FBXW7 is a general tumor suppressor and its mutations have been found in a variety of human cancers.Particularly, FBXW7 mutations occur in nearly 10-15% of colorectal cancer (CRC), ranking it the fourth most commonly mutated gene after APC, KRAS, and TP53.It has been widely accepted that sequential mutations in the master regular genes and concomitant accumulation of these mutations eventually trigger tumorigenesis and metastasis.Our hypothesis is that the failsafe role of FBXW7 in CRC could probably be the very last defense mechanism against tumor formation and progression, and its downturn allows malignant cells to adopt the mechanism of dissemination and thus switch to metastatic growth.
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