【摘 要】
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It is no doubt that methylation plays an important role in breast cancer development and progression.Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may l
【机 构】
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Obstetrics and Gynecology Hospital of Fudan University China
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It is no doubt that methylation plays an important role in breast cancer development and progression.Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy by deregulation of cell and growth cycles.Our previous works identified two panels of methylation profiles: HIN-1/RASSFIA panel strongly correlated to the expression of ERs, PRs, and hormone receptors (HR); conversely, the methylation of the RIL/CDH 13 panel strongly correlated to negative ER, PR, and HR expression.To confirm this finding, we have enlarged the sample size, 193 subjects were selected with breast cancer at stage I or IIA at diagnosis, and without adjuvant therapy.
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