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Germline mutations are responsible for familial cancer syndromes which account for approximately 5～10 ％ of all types of cancers.These mutations mainly occur at tumor suppressor genes or genome stability genes,such as DNA repair genes,rarely at proto-oncogenes.Here we have identified a cancer predisposition family,in which seven members were inflicted with a wide spectrum of cancer including one diagnosed with lung cancer at 22 year-old.