Structural insights into arginine methylation by a type Ⅲ PRMT

来源 :2013年第四届全国“跨学科蛋白质研究”学术讨论会 | 被引量 : 0次 | 上传用户：susanna2005

【摘要】

：

　　Arginine methylation plays vital roles in numerous biological processes, such as transcription regulation, RNA processing, DNA repair and signal transductio

【作者】

：

王崇元滕脉坤吴季辉 Joan M Hevel 施蕴渝朱玉威 Tamar B Caceres 彭俊辉王军成陈佳婧陈旭文张志勇龚庆国

【机构】

：

中国科学技术大学生命科学学院,合肥微尺度物质科学国家实验室,合肥230027ChemistryandBiochemistryDepartment,UtahStateUniversity,0300Old

【出处】

：

2013年第四届全国“跨学科蛋白质研究”学术讨论会

【发表日期】

：

2013年10期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Arginine methylation plays vital roles in numerous biological processes, such as transcription regulation, RNA processing, DNA repair and signal transduction.Protein arginine methyltransferases (PRMTs) catalyze the methylation on guanidino groups of arginine residues, which are categorized into three types.

其他文献

热诱导DegP6解聚路径的脉冲升温时间分辨红外光谱研究

　　大肠杆菌DegP是热休克蛋白家族的一员,具有蛋白酶和分子伴侣双重活性.DegP以三聚体为最小结构单元,构成六聚体、十二聚体、二十四聚体等尺寸和功能各异的寡聚体形式.在静

会议

Structural, functional and pathological aspects of the TDP-43 aggregation

　　TAR DNA binding protein of 43 kDa (TDP-43) is a major deposited protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ub

会议

TDP-43TDP-35aggregationinclusionmRNAamyloidogenic coreRNP granules

Interaction with polyglutamine-expanded ataxin-7 alters the function of ubiquitin-specific protease

　　Ataxin-7 (Atx7) is a subunit of the DUB module (DUBm), which is a component of the mammalian STAGA transcription coactivator complex.Its polyglutamine (Poly

会议

Ataxin-7USP22PolyQinclusionSCA7

Polyproline stretch intramolecularly regulates the interaction of HYPBSETD2 with huntingtin

　　Huntingtons disease (HD) is a progressive neurodegenerative disorder of the central nervous system, which is caused by the polyglutamine (polyQ) expansion i

会议

huntingtinHYPB/SETD2proline-rich regionWW domainpolyprolineintramolecular i

Regulation of NEDD8 Degradation by NUB1L through the P97VCP Complex

　　NEDD8 is a ubiquitin-like protein which regulates pivotal biological processes by conjugating to client proteins.NEDD8 and neddylation are negatively regula

会议

NEDD8NeddylationNUB1LP97/VCPCullin 1

Efficient production and biological activity characterization of the human chemokine receptor CCR3

　　G-protein-coupled receptors (GPCRs) are the largest family of membrane protein and mediate most of the transmembrane signal transduction.Human chemokine rec

会议

Probing the folding, unfolding of bacteriorhodopsin by SM-FRET

　　In contrast to a large number of work of water soluble proteins folding.Little is known about the structural properties of membrane proteins which is diffic

会议

foldingunfoldingSM-FRETconformational change

Cytoplasmic USP19 regulates polyglutamine-expanded proteins through an HSP90 chaperone complex

　　Proteins with an aberrant extension of polyglutamine (polyQ) are the main pathological causes of neurodegenerative polyglutamine diseases.Among these, spino

会议

USP19HSP90ataxin-3polyQaggregationCHIPSCA3

Probing allosteric effect through DNA by single-molecule technique and structural analyses

　　In proteins, conformational change impacting biological function has been well-investigated in the past decades, which has been generally named allosteric e

会议

揭示超大分子复合物的组装

　　生命活动的很多基本过程是与系统的结构层次密切相关的。较高级的细胞结构层次显示出蛋白质、核酸等生物大分子单独所不具备的生命特征。在较复杂的系统层次上对生物大分

会议

Structural insights into arginine methylation by a type Ⅲ PRMT

其他学术论文