PAQR9 promotes HFD-induced fatty liver by impairing thermogenesis

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：blue1234sky

【摘要】

：

【作者】

：

Xue You Yan Chen

【机构】

：

CAS Key Laboratory of Nutrition and Metabolism,Institute for Nutritional Sciences,Shanghai Institute

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

PAQR9 Obesity

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　PAQR9 is a member of the PAQR(progestin and adipoQ receptor)family,however,the investigation of obesity by PAQR9 has not been known.PAQR9 knockout(KO)mice are resistant to high fat diet(HFD)-induced obesity,due to PAQR9-KO mice have lower body weight and fat mass than wild type(WT)when they are fed a HFD.

其他文献

rBTI Alleviate the Age-dependent Functional Decline through DAF-16 in Caenorhabditis elegans

With an aging society in the speed,improvement of the physical function status and quality of life is more meaningful than a longer-living in the elderly.Previous studies have shown that a recombinant

会议

rBTIAgingProteostasisMitochondriaDAF-16

Antioxidant Peptide Purified from Enzymatic Hydrolysates of Isochrysis Zhanjiangensis and its Protec

Marine microalgae have been widely applied in cosmaceuticals,nutraceuticals,and functional foods.In the present study,we first investigated the hepatoprotective effects of peptide purified from microa

会议

Isochrysis zhanjiangensisPeptideEnzymatic hydrolysatesFree radical scavenging

Biocatalytic Preparation of Chiral Sulfoxides by recombinant Methionine Sulfoxide Reductase A

Chiral sulfoxides are valuable organosulfur compounds and have been widely used as important intermediates in asymmetric synthesis and as bioactive ingredients in pharmaceutical industry.Asymmetric bi

会议

Methionine sulfoxide reductase Arecombinant enzymechiral sulfoxidesbiocatalys

Roles of N-terminal Asparagine Amidohydrolase Gene from Apis cerana cerana in Oxidative Stress Respo

N-terminal asparagine amidohydrolase(Ntan1)is a feature of the ubiquitin-dependent N-end rule pathway of protein degradation which has been implicated in a legion of physiological functions: sensing o

会议

N-terminal asparagine amidohydrolaseOxidative stressRNA inferenceApis cerana

Novel Inhibitors of Lon Protease Reduce Bacterial Persister Formation

Bacterial persister is a sub-group of special population of bacteria,and has the distinction marks from the ordinary bacteria and resistant mutants.The presence of persister is believed to be closely

会议

Lon proteaseToxin-antitoxin systemPersisterPeptidyl boronic acid

半乳糖硫酸酯结构单位的功能研究

蛋白质或者脂类分子经过糖链修饰后形成糖蛋白或糖脂。糖链的半乳糖具有3羟基结构，我们的研究发现糖链半乳糖的3O硫酸酯修饰可以形成一种特殊结构单元，我们称之为半乳糖硫酸酯结构单位。这种特殊的结构单元见于人体组织中的重要分子中，其调节功能和活性作用正受到重视。

会议

糖链半乳糖硫酸酯结构单位肿瘤转移整合素

聚球藻PCC7942中糖原积累与蔗糖合成代谢关系的新视点

很多蓝细菌在高盐环境下在胞内合成蔗糖来抵抗逆境。利用这一生理特点，利用基因工程手段已能实现蓝细菌中蔗糖的高效合成与分泌，但该过程背后的若干基础理论仍有待揭示。由于蓝细菌中蔗糖合成与糖原合成使用相同的前体物——葡萄糖-1-磷酸，一般认为二者之间存在合成竞争关系，抑制糖原合成将能促进蔗糖合成。然而，我们研究结果表明情况并非如此。

会议

蓝细菌盐胁迫蔗糖合成糖原

Function of TXNIP on lipid accumulation in LO2 cell

Thioredoxin interacting protein(TXNIP)plays an important role in glucose-lipid metabolism.Fatty acid synthase(FASN)catalyzes the last step in fatty acid biosynthesis,and thus,it is believed to be a ma

会议

Thioredoxin interacting proteinlipid accumulationhepatic cells

YY1-mediated suppression of fatty acid oxidation is critical for cancer cell proliferation

Fatty acid is the main organic molecule composing the cell membrane,and thus is critical in biomembrane synthesis.In normal cells,balance of the fatty acid biosynthesis and fatty acids β-oxidation det

会议

YY1HIF-1α-independentPGC-1βtumor cells lipid metabolism

转录因子YY1通过直接激活磷酸戊糖途径促进肿瘤细胞增殖

肿瘤细胞由于其自身的快速增殖、应对氧化应激和对生物大分子的需求会改变其自身代谢。转录因子阴阳1(YY1)在多种肿瘤中呈高表达，并且对肿瘤细胞增殖和转移发挥重要作用。然而，它在肿瘤细胞代谢重编程中是否起到调控作用尚未有报道。

会议

YY1磷酸戊糖途径(PPP)葡萄糖六磷酸脱氢酶(G6PD)细胞代谢重编程p53非依赖性

PAQR9 promotes HFD-induced fatty liver by impairing thermogenesis

其他学术论文