Radiation-Induced ADME Gene Expression: A Tangled Web of NRs, TFs and miRNAs

• 作 者: HongjianZHANG;
• 机 构: 苏州大学药学院
• 出 处: 2015第11届全国药物和化学异物代谢学术会议
• 发表日期: 2015年期

　　Drug metabolizing enzymes (DMEs) and transporters play important roles in the efficacy and safety of many drugs.As key biochemical mechanisms participated in drug disposition, the expression of DMEs and transporters is regulated via a network of nuclear receptors (NRs) and transcriptional factors (TFs).