自身免疫性肝炎患者肝内Kv1.3钾离子通道数量变化的意义

来源 :中华医学会第十六次全国病毒性肝炎及肝病学术会议 | 被引量 : 0次 | 上传用户：stephenlyx

【摘要】

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【作者】

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赵雨来刘树红李文淑张潇周光德郭晓东赵景民

【机构】

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中国人民解放军第三○二医院病理诊断与研究中心中国人民解放军第三○二医院新药临床实验中心

【出处】

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中华医学会第十六次全国病毒性肝炎及肝病学术会议

【发表日期】

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2013年7期

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目的研究自身免疫性肝炎(Autoimmune Hepatitis,AIH)患者肝组织内Kv1.3钾离子通道及CD4+ CD25+调节性T细胞(Treg细胞)的数量变化情况,探讨Kv1.3钾离子通道在AIH发病中的潜在作用.方法应用免疫组织化学染色方法进行Kv1.3、Foxp3和CD3染色,比较AIH患者(20例)和慢性乙肝(Chronic Hepatitis B,CHB)患者(20例)肝组织内Kv1.3和Treg细胞数量的变化.结果免疫组化染色发现,在肝组织中AIH患者Kv1.3+细胞数显著高于CHB患者,而AIH患者Foxp3+细胞/CD3+细胞的比例显著低于CHB患者.结论 Kv1.3钾离子通道数量的增多可能是AIH发病的一个因素.

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自身免疫性肝炎患者肝内Kv1.3钾离子通道数量变化的意义

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