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Background HBeAg-negative chronic hepatitis B (CHB) patients have active liver disease with a high risk of progression to decompensated cirrhosis and hepatocellular carcinoma.The management strategy of chronic hepatitis B with HBeAg-negative for patients treated with nucleos (t) ide analogues (NUCs) is a topic of concern.To observe the outcomes after NUCs withdrawal, HBeAg-negative CHB patients with achieving HBsAg loss or sustained undetectable HBV DNA levels and discontinued NUCs therapy were included in the study.