血清IL-1RA水平与非酒精性脂肪性肝病的相关性及无创诊断研究

来源 :中华医学会第十六次全国病毒性肝炎及肝病学术会议 | 被引量 : 0次 | 上传用户：rooku

【摘要】

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【作者】

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杨美郭晓东章方莉李文淑周光德刘树红郭超楠赵雨来赵景民

【机构】

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中国人民解放军第三○二医院病理诊断与研究中心中国人民解放军第三○二医院新药临床实验中心

【出处】

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中华医学会第十六次全国病毒性肝炎及肝病学术会议

【发表日期】

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2013年7期

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目的非酒精性脂肪性肝病(NAFLD)尤其是其关键阶段非酒精性脂肪性肝炎(NASH)已成为全球最重要的公共健康问题之一.病理检查是NASH诊断的"金标准",但属有创诊断,不被患者接受.无创诊断是NASH诊治的必然发展方向,但目前缺乏令人满意的无创诊断、预测NASH指标.本研究探究血清白介素-1受体拮抗剂(IL-1RA)与NAFLD进展的相关性,无创性预测诊断NASH.方法选取确诊NAFLD病例60例,配套肝穿刺活检组织标本及肝穿前一周血清.经B超检查无脂肪肝症状的正常健康人群30例,作为对照.测量身高、体重、腰围等生理指标,计算BMI;检测ALT、AST、AST/ALT、ALP、GGT、TC、TG、HDL、LDL等生化指标;双抗夹心法测定血清中IL-1 RA浓度水平.

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血清IL-1RA水平与非酒精性脂肪性肝病的相关性及无创诊断研究

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