Novel and Potent HIV-1 NNRTIs Research:Design,Synthesis and Biological Evaluation

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：haoxuexi0825

【摘要】

：

【作者】

：

Xinyong Liu Peng Zhan Xuwang Chen Wenmin Chen Ye Tian Xiao Li Christophe Pannecouque Jan Balzarini Erik De Clercq

【机构】

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Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Shandong University

【出处】

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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　Aquired Immune Deficiency Syndrome(AIDS) caused by human immunodeficiency virus(HIV),is still prevalent worldwide.The most efficient and standard treatment regimen for HIV-1 infection,namely as highly active antiretroviral therapy(HAART),commonly involves two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitors(PIs) or a non-nucleoside reverse transcriptase inhibitors(NNRTIs).As a key component of HAART,NNRTIs play important role in the currently clinical AIDS therapies because of their high potency and specificity.

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