【摘 要】
：
Poly(ADP-ribose) polymerase-1(PARP-1)(ADP,adenosine diphosphate) is a 113kDanuclear protein that is involved in the signaling of DNA damageto recognize and to rapidly bind DNA singleordouble-strand br
【机 构】
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Synthetic Organic and Medicinal Chemistry Laboratory(SOMCL),Shanghai Institute of Materia Medica(SIM
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Poly(ADP-ribose) polymerase-1(PARP-1)(ADP,adenosine diphosphate) is a 113kDanuclear protein that is involved in the signaling of DNA damageto recognize and to rapidly bind DNA singleordouble-strand breaks.PARP-1 is also capable of catalyzing thetransfer of ADP-ribose units from intracellular nicotinamideadenine dinucleotide(NAD+)to target proteins that mediate gene amplificationand transcriptional regulation,cell division and differentiation,as well as apoptosis and chromosome stability.Therefore,PARP-1 has emerged as apromising molecular drug target of cancer therapy.
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