Discovering Lead Compounds for Treatment of Prion Diseases

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：wuww

【摘要】

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【作者】

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Beining Chen

【机构】

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Dainton Building,Department of Chemistry,University of Sheffield,Brookhill,Sheffield S3 7HF,United K

【出处】

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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

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2012年8期

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　　Prion diseases,or transmissible spongiform encephalopathies(TSEs),are a family ofrapidly progressive,invariably fatal,neurodegenerative disorders affecting both humans and animals,for which no effective therapy is currently available.These diseases share a common pathologicalpathway where normal cellular prion proteins(PrPC) undergo conformational changes into theirabnormal counterparts(PrPSc).Well known prion diseases include scrapie in goats,bovinespongiformencephalopathies(BSE,mad cow disease),and Creutzfeldt-Jakob disease in human etc.

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Discovering Lead Compounds for Treatment of Prion Diseases

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