A Complexity-Based Planning Strategy for Efficient Diverted Total Synthesis of Macrolides and Analog

• 作 者: Wei-Min Dai
• 机 构: Department of Chemistry,The Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,H
• 出 处: 第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
• 发表日期: 2012年8期
• 关键词: diverted total synthesis macrolides structural complexity synthetic strategy

　　A complexity-based planning strategy for designing the most efficient synthetic routes is illustrated in Scheme 1.PS-b features a common intermediate Ⅳ,of higher degree of structural complexity,for synthesis of a collection of targets Ⅴ.In contrast,PS-a shares the common intermediate Ⅱ and requires much more parallel operations toward the same targets Ⅴ.Total syntheses of amphidinolide T1-T51 and X/Y,2 and iriomoteolide-1a3 are discussed.