Design,Synthesis and Antitumor Activities of 3'-Azido-Epirubicin

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：youpi100

【摘要】

：

【作者】

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Qingfeng Liu Wenpeng Zhang Duxin Sun Guisheng Zhang

【机构】

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College of Chemistry and Environmental Science,Key Laboratory of Green Chemical Media and Reactions,

【出处】

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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　Anthracyclines are considered to be some of the most effective anticancer drugs for cancer therapy,but are limited by drug-resistance and cardiotoxicity.To overcome drug resistance,we designed a 3-azido analogue of Epirubicin(AEPI)based on molecular docking with multidrug-resistance protein Sav1866.AEPI was synthesized through transforming the amino group of Epirubicin to an azido group.

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Design,Synthesis and Antitumor Activities of 3'-Azido-Epirubicin

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