【摘 要】
：
Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases characterized by accumulation of α-synuclein (α-syn).Geniposide (Gde) is
【机 构】
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School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China
【出 处】
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The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
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Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases characterized by accumulation of α-synuclein (α-syn).Geniposide (Gde) is a major iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis., which has been widely used in traditional Chinese medicine.In this study, the novel function of Gde as a neuronal autophagy inducer was reported.Gde induced autophagy in different neuronal cell lines, including N2a,PC12 and SH-SY5Y cells.Moreover, Gde promoted autophagy in Drosophila fat body and in the brain of ICR mice.The neuroprotective effect of Gde was evaluated on Drosophila PD model overexpressing wild-type α-synuclein (WT-αsyn).Gde down-regulated the expression level of WT-αsyn in the brains of the flies.The motor function of the flies receiving Gde was improved.The loss of dopaminergic neurons was also ameliorated by Gde.Collectively, we have identified Gde as a neuronal autophagy inducer, which can promote the clearance of WT-αsyn and protect neurons.
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